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what is tianeptine sodium

Tianeptine sodium is an antidepressant from the group of tricyclic derivatives.

Tianeptine most popular brands stablon and tynept available at Modathrust online pharmacy buy now.

Increases the reverse neuronal uptake of serotonin by neurons of the cerebral cortex and hippocampus increases the hippocampus’s pyramidal cells’ spontaneous activity and accelerates the recovery of their potential after functional inhibition. Improves mood, eliminates motor lethargy, increases the general tone of the body. 

The patient behaviour during alcoholism the time of Abstinence. It occupies an intermediate position between sedative and stimulant antidepressants. Antidepressant and anxiolytic action helps to eliminate somatic complaints due to anxiety and mood changes. It has little effect on the cardiovascular system, sleep, the psychomotor reaction’s speed, and the parasympathetic nervous system.

There is proof of tianeptine sodium interaction with the glutamatergic system and that it appears to be an agonist of μ-opioid receptors. When used frequently in high doses, it is addictive and can be used as a drug with severe and fatal consequences.

Tianeptine direct

  • Depressive states of minor, moderate and severe severity (including in the elderly and patients with chronic alcoholism during the withdrawal period);
  • anxiety-depressive state (with somatic complaints);
  • organic depressive and anxiety disorders; 
  • acute reaction to stress; 
  • post-traumatic stress disorder;
  • Neurasthenia.

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Contraindications

  • Hypersensitivity to tianeptine;
  • simultaneous intake of non-selective MAO inhibitors;
  • pregnancy;
  • lactation;
  • children and youngsters (up to 15 years).

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Method of treatment and dosage (stablon dosage)

Within, before meals, 12.5 mg 3 times a day. In patients over 70 years of age and with severe chronic renal failure – 12.5 mg 2 times a day.

Side effects

From the nervous system and sensory organs

Dizziness, headache, insomnia, daytime sleepiness, decreased concentration, nightmares, asthenia, lipotimia, fainting, tremor.

Overdose

The experience of an overdose of tianeptine (the maximum amount was 2250 mg per dose) revealed the following signs and symptoms: confusion, convulsions, drowsiness, dry mouth and respiratory failure, mainly when the tianeptine combined with alcohol.

In all overdose cases, you should stop taking the drug and carry out medical monitoring of the patient.If necessary,

you should:

  • if took the drugs less than 2 hours before hospitalization, then gastric lavage should be performed. If for a longer time, then it is necessary to take activated carbon;
  • monitor the functions of the cardiovascular and respiratory systems, kidney function, homeostasis indicators

Specific antidotes for tianeptine are unknown.

Influence on the ability to drive vehicles and use mechanisms

In some patients, the ability to concentrate and the speed of psychomotor reactions may decrease. Therefore, during treatment, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Nootropil how to take to improve memory

The term “nootropics” comes from the words “noos” – “mind” and “tropos” – “nutrition.”

Nootropic drugs have a specific activating effect on the brain’s integrative functions: agents that positively impact learning, improve memory and mental activity, and increase the body’s resistance to aggressive influences. The ability to improve cognitive function has led to the designation of these drugs as cognitive stimulants.

Several doctors suggest using Piracetam for all persons over forty years of age to maintain intellectual activity at an average level.
Also, all students should take Piracetam before exams. However, it must be borne in mind that its nootropics effect appears after about 3 to 4 weeks, nootropil buy so start taking it for improve memory, facilitate learning, etc. follows one month before the start of the desired action

Piracetam comes in drugstores under two names: 

Piracetam and nootropil. The generic drug is called Piracetam; the brand drug is called nootropil. The difference between them is in price; Piracetam is much cheaper than nootropil, and, according to rumours, in the degree of purification. Piracetam is cleared less efficiently and therefore, with prolonged use, problems with the liver or kidneys may occur.

Nootropil, Piracetam.

Nootropil 800 affects the central nervous system in various ways:

It accelerates the transmission of nerve impulses in the brain and improves the metabolic background and microcirculation, without exerting a vasodilating effect.

Nootropil is a psychotropic drug that directly affects the brain, improving its functions in healthy and sick people.

Nootropil does not have a sedative and psychostimulating effect.

The results of long-term therapy with Nootropil in patients with functional disorders of the central nervous system demonstrated an improvement in recognition and an increase in the level of wakefulness.

In the case of dysfunctions of the brain due to hypoxia and intoxication, as well as after conducting electroshock therapy, Nootropil has a protective effect and restores the recognition deficit.

Nootropil reduces the severity of vestibular nystagmus.

In patients with dementia due to repeated violations of cerebral circulation, Nootropil improves the brain’s local uptake of oxygen and glucose.
Nootropil inhibits the aggregation of activated platelets and restores the outer membrane’s configuration properties of rigid erythrocytes and the latter’s ability to pass through the vessels of the microvasculature.

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Pharmacokinetics.

When taken orally, Nootropil is rapidly and almost completely absorbed. Bioavailability is about 100%. The maximum concentration of Piracetam in plasma is reached 30 minutes after ingestion of 2 g and is 40 – 60 μg / ml. The maximum concentration of Piracetam in the cerebrospinal fluid is earned after 2 to 8 hours.

Indications:

  1. memory impairment, dizziness, mood changes, behavioural disorders and erasure of personality traits in old age, in patients with Alzheimer’s disease, as well as for symptomatic therapy as part of the complex treatment of symptoms of dementia, including due to repeated disorders of cerebral circulation;
  2. stroke treatment;
  3. coma of vascular, traumatic or toxic origin;
  4. lack of recognition function in traumatic brain injury;

treatment of withdrawal syndrome and psychogenic syndrome in chronic alcoholism
for the correction of learning ability in children, especially in cases of a decrease in the ability to recognize text and write words that cannot be explained by mental retardation, short learning, or the family environment’s peculiarities.

Piracetam dosage.

The daily dose of Nootropil varies from 30 to 160 mg/kg of body weight. The drug can be prescribed two times/day, however, if necessary, the daily dose of Nootropil 800 can be divided into 3 – 4 doses.

Nootropil is a non-toxic drug. Therefore, there is no need to resort to any special measures in case of an overdose.

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Modafinil is an exciting drug. It has narcoleptics from falling asleep, and it also seems to help people with Attention Deficit Disorder (ADD), and Attention Deficit Hyperactive Disorder (ADHD) stay focused.

For example, the completion of inspections of enantiopure escitalopram versus racemic citalopram has combined results. Some single analysis that escitalopram isn’t better or more critical than citalopram along with other SSRI antidepressants (e.g. Svensson & Mansfield 2004); others, including meta-analyses (studies of studies), show that it is far better or even have fewer adverse effects (e.g. Kennedy et al. 2006).

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Dysthymic disorder –

This is the term for a small to moderate a higher level of depression that persists for about 2 yrs, and infrequently longer. While the symptoms aren’t as severe as a significant depression, they may be more enduring and proof against treatment. Some people with dysthymia establish a major depression sooner or later during their depression.

But how efficient is Modafinil for ADHD?

 

That depends entirely on which study you review since modafinil shows mixed ends in studies linked to ADHD treatment. The results of merely one study published in July 2000 were so disappointing that the manufacturer from the medication, Cephalon Inc., decided to pursue other drug indications. Then, in February 2001, the Journal from the American Academy of Child and Adolescent Psychiatry published the outcomes of any study that indicated potential good thing about Provigil settlement (modafinil) to be a once-daily ADHD treatment. The most recent research, performed by the maker to gain FDA approval, showed “significant improvement” than the placebo.

What are stem cells and why a great deal buzz regarding their pharmaceutical perspective? These stem cells bring great wish for the pharmaceutical researchers to find remedies against deadly diseases. For example, if they’re injected in patients, the stem cells can regenerate and replenish the bone marrow and the body’s defence mechanisms possibly damaged by chemotherapy and radiotherapy.

For example, the completion of inspections of enantiopure escitalopram versus racemic citalopram has combined results. Some single analysis that escitalopram isn’t better or more critical than citalopram along with other SSRI antidepressants (e.g. Svensson & Mansfield 2004); others, including meta-analyses (studies of studies), show that it is far better or even have fewer adverse effects (e.g. Kennedy et al. 2006).

Modafinil manufacturer got FDA approval for Attenace. By achieving FDA approval for Attenace manufacturer will be allowed to market modafinil for ADHD.

This is mostly a right choice for nighttime workers, truckers, doctors, and nurses on night duty and individuals who need to stay awake for various reasons, such as young nursing mothers, students, and individual ambitious professionals. Due to insufficient proper night sleep or inadequate sleep, these folks endure low energy, fatigue, drowsiness and excessive tiredness in addition to body aches.

 

What is modafinil and where to buy modafinil ?

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The impulse to sleep when you need to be awake can cause innumerable hurdles in your daily life. Feeling sleepy during the day will not only affect your productivity at work but will also wreak havoc in your social life. Above all, because you are prone to sleepiness during the day, you will not sleep at night. All these symptoms will affect your health adversely, causing physical and emotional distress and psychological problems. In case you are suffering from such sleep-associated issues, then you require immediate help.

Modafinil is a nootropics expert drug approved by the FDA to treat patients with narcolepsy. In this condition, one cannot stay awake during the daytime and other sleep disorders like obstructive sleep apnea or hypopnea and shift work sleep disorders.

Modafinil works by stimulating the central nervous system, which helps people suffering from daytime sleep disorders to stay awake and attentive.

Modafinil comes in convenient 200 mg dosages; a typical dosage is usually taken once every day in the morning. Modafinil can be used for short term or long term, but it is always advisable to consult your physician before taking any medication.

This FDA approved drug can help with your constant state of drowsiness and stimulate your body to keep you active with a balanced amount of energy and attentive on the tasks at hand.

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